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Pancreatic Ductal Adenocarcinoma The treatment of pancreatic ductal adenocarcinoma (PDAC) is particularly challenging due to its dense fibrotic stroma, which not only protects cancer cells from immune system attacks but also impedes drug penetration and distribution, rendering standard chemotherapy regimens less effective

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In vitro , SCFAs could suppress astrocyte activation by inhibiting NF-κB signaling (Ryu et al., 2019)

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